Development of inactivated poliovirus vaccine derived from Sabin strains.
Biologicals
; 34(2): 151-4, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16679028
ABSTRACT
In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys.
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Banco de datos:
MEDLINE
Asunto principal:
Vacuna Antipolio de Virus Inactivados
Límite:
Animals
Idioma:
En
Año:
2006
Tipo del documento:
Article