Cellular and biochemical parameters of exercise-induced oxidative stress: relationship with training levels.
Free Radic Res
; 40(6): 607-14, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16753838
ABSTRACT
To better clarify the relationship between physical activity and oxidative stress, we determined the effects of a maximal test in 18 young subjects with different training levels (six professional Athletes and 12 non-agonists (NA)). Redox homeostasis (total antioxidant activity (TAS), vitamin C and glutathione (GSH)), oxidative damage (diene conjugation and hemolysis), lymphocyte cell death and repair systems (apoptosis, micronuclei and Hsp70 expression) were evaluated. We found that agonistic training led to a chronic oxidative insult (high baseline values of oxidized glutathione (GSSG), micronuclei and hemolysis). On the contrary, NA with the lowest level of training frequency showed a well balanced profile at rest, but they were more susceptible to exercise-induced variations (GSSG/GSH and diene increased values), respect to the NA with an higher level of training. As almost all the parameters employed in this study showed inter-individual variations, the GSSG/GSH ratio remains the most sensitive and reliable marker of oxidative stress, accordingly with other data just reported in the literature.
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Banco de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Aptitud Física
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Estrés Oxidativo
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Año:
2006
Tipo del documento:
Article