Mitochondrial transhydrogenase--a key enzyme in insulin secretion and, potentially, diabetes.
Trends Biochem Sci
; 31(7): 355-8, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16766189
ABSTRACT
Two recent studies have shown that the glucose intolerance and impaired insulin secretion of the C57BL/6J mouse strain results from oxidative stress due to a mutated nicotinamide nucleotide transhydrogenase. Reproduction of this phenotype, by mutating the same enzyme in another strain with normal glucose tolerance, suggests that the mechanism of the transhydrogenase-dependent inhibition of insulin secretion involves a partial uncoupling by the UCP2 protein. These exciting findings raise important questions, not least their potential relevance for human diabetes.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Intolerancia a la Glucosa
/
Insulina
/
NADP Transhidrogenasas
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Año:
2006
Tipo del documento:
Article