Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication.
Schizophr Res
; 6(1): 41-8, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1686183
ABSTRACT
The specific binding of [3H]TCP and [3H](+)3-PPP, radioligands which respectively label PCP-NMDA and sigma binding sites was measured in tissue homogenates prepared from dissected areas of control and schizophrenic postmortem brains. [3H]TCP binding was bilaterally increased in orbital frontal cortex (Brodmann area 11) of schizophrenic brains. This finding may be due to an increased glutamatergic innervation of orbital frontal cortex since it parallels our findings of increased [3H]kainate and [3H]D-aspartate binding in this area. In contrast, [3H](+)3-PPP binding was reduced in each of the four brain regions examined. The reductions were greatest in brains from the schizophrenic subjects receiving neuroleptics at the time of death. Neuroleptics remaining in the brains of these subjects may compete in vitro with [3H](+)3-PPP for binding to the sigma site.
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Banco de datos:
MEDLINE
Asunto principal:
Fenciclidina
/
Esquizofrenia
/
Psicología del Esquizofrénico
/
Antipsicóticos
/
Receptores de Neurotransmisores
/
Receptores Opioides
Límite:
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Año:
1991
Tipo del documento:
Article