Beta-catenin and E-cadherin expression in salivary gland tumors.
Int J Surg Pathol
; 14(3): 212-7, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16959701
ABSTRACT
This study evaluated the expression of E-cadherin and beta-catenin in salivary gland tumors. Twelve biopsy specimens from cases diagnosed as pleomorphic adenoma, 17 adenoid cystic carcinomas, 10 epithelial-myoepithelial carcinomas, and 4 polymorphous low-grade adenocarcinomas were immunohistochemically labeled for E-cadherin and beta-catenin antibodies. Healthy salivary glands were used as controls. Membrane-associated E-cadherin and beta-catenin expression was present in all the tumor types studied. E-cadherin and beta-catenin showed a similar distribution; however, beta-catenin labeling was weaker than that for E-cadherin. In the epithelial-myoepithelial carcinomas, myoepithelial cells exhibited diffuse nuclear staining, although occasional cells presented only focal labeling. Epithelial-myoepithelial carcinomas present changes in [.beta]-catenin expression but the other salivary tumors studied do not, which may reflect divergence in tumorigenesis of this extensive subset of salivary gland tumors.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de las Glándulas Salivales
/
Adenocarcinoma
/
Adenoma
/
Cadherinas
/
Carcinoma Adenoide Quístico
/
Mioepitelioma
/
Beta Catenina
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2006
Tipo del documento:
Article