Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties.
J Antibiot (Tokyo)
; 59(10): 664-8, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-17191683
ABSTRACT
The novel macrolide cruentaren A was produced at levels up to 3.2 mg/liter by cultures of the myxobacterium Byssovorax cruenta. The new compound strongly inhibited the growth of yeasts and filamentous fungi and showed high cytotoxicity against L929 mouse fibroblast cells. A minor co-metabolite of cruentaren A, named cruentaren B, and identified as a six-membered lactone isomer of cruentaren A, showed only marginal cytotoxicity and no antifungal activity. Cruentaren A inhibited F0F1 mitochondrial ATP-hydrolysis in submitochondrial particles of yeasts and beef heart.
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Banco de datos:
MEDLINE
Asunto principal:
Macrólidos
/
ATPasas de Translocación de Protón Mitocondriales
/
Isocumarinas
/
Antifúngicos
Límite:
Animals
Idioma:
En
Año:
2006
Tipo del documento:
Article