BLISS index for analyzing knee osteoarthritis trials data.
J Clin Epidemiol
; 60(2): 124-32, 2007 Feb.
Article
en En
| MEDLINE
| ID: mdl-17208118
ABSTRACT
OBJECTIVES:
Different pain thresholds were investigated, using the WOMAC Pain Scale (WOMAC-P) to determine if they could differentiate between treatment groups (hylan G-F 20 vs. appropriate care) at low and very low levels of state attainment in patients with knee osteoarthritis (OA). A method, termed the BLISS (Bellamy et al. Low Intensity Symptom State-attainment) Index, for analyzing OA knee clinical trials data, was proposed. STUDY DESIGN ANDSETTING:
Five analyses were performed time to first BLISS day, BLISS days over 12 months, patients with a BLISS response at month 12, patients with a BLISS response at any time, and number of BLISS periods over 12 months. For each analysis, five levels of WOMAC-P were examinedRESULTS:
More patients in the hylan G-F 20 group achieved BLISS states in all five analyses. These differences were statistically significant for all pain threshold levels except
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Banco de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
/
Dimensión del Dolor
/
Interpretación Estadística de Datos
/
Osteoartritis de la Rodilla
/
Ácido Hialurónico
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2007
Tipo del documento:
Article