In vivo adaptation of the Wayne model of latent tuberculosis.
Infect Immun
; 75(5): 2621-5, 2007 May.
Article
en En
| MEDLINE
| ID: mdl-17283091
ABSTRACT
Cultures of Mycobacterium tuberculosis grown under oxygen depletion conditions enter into a state of nonreplicating persistence that may reflect a physiologically latent state. When these cultures were harvested and injected intranasally into mice, no bacteria could be recovered from the lungs for about 3 weeks, but after that evidence of regrowth was observed. Preimmunization of mice with a panel of selected vaccine candidates slowed or prevented this event. This simple model has potential for identifying vaccines targeting latent tuberculosis.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Tuberculosis Pulmonar
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Adaptación Fisiológica
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Modelos Animales de Enfermedad
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Mycobacterium tuberculosis
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article