A comparison of the effects of the CB(1) receptor antagonist SR141716A, pre-feeding and changed palatability on the microstructure of ingestive behaviour.
Psychopharmacology (Berl)
; 193(1): 1-9, 2007 Jul.
Article
en En
| MEDLINE
| ID: mdl-17372721
ABSTRACT
RATIONALE The cannabinoid CB(1) receptor inverse agonist SR141716A (rimonabant) is known to cause hypophagia and this study uses microstructural data to elucidate the relevant behavioural mechanisms. OBJECTIVES:
The aim of these studies was to determine the behavioural changes induced by SR141716A in animals consuming either a fat or carbohydrate solution. These behavioural changes were directly compared with those induced by behavioural manipulations that modify motivational state and palatability.METHODS:
Male hooded Lister rats drank a highly palatable fat emulsion (10% Intralipid) or a carbohydrate solution (10% sucrose) during 30-min test sessions. Microstructural analyses of licking patterns were made after either administration of SR141716A (0, 0.3, 1 and 3 mg/kg, ip) or one of the after behavioural manipulations pre-feeding, addition of quinine to the fat solution or changes in sucrose concentration.RESULTS:
Intake of the fat solution was decreased after both the drug treatment and the behavioural manipulations of pre-feeding and addition of quinine. Pre-feeding and SR141716A-induced reductions were mediated via changes in bout number whereas addition of quinine caused a decrease in bout size. Although sucrose drinking was also decreased by pre-feeding, reduced sucrose concentration and SR141716A, the drug did not significantly alter the microstructure of intake.CONCLUSIONS:
The effects of SR141716A on consumption of Intralipid solutions are likely to reflect changes in motivational state rather than modified hedonic impact.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Pirazoles
/
Receptor Cannabinoide CB1
/
Ingestión de Alimentos
/
Conducta Alimentaria
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article