[Circadian clock gene expression in human peripheral blood mononuclear cells]. / Expression des gènes de l'horloge circadienne dans les cellules sanguines mononuclées humaines.
Pathol Biol (Paris)
; 55(3-4): 208-10, 2007.
Article
en Fr
| MEDLINE
| ID: mdl-17412523
ABSTRACT
Circadian clock genes have been identified in humans but information regarding their expression has remained very limited. However from a basic point as well as in a diagnostic and therapeutic perspective, it is important to evaluate molecular clock gene expression. Peripheral blood mononuclear cells represent an ideal material to investigate non-invasively the human clock at the molecular level. Several studies including ours reported rhythmic expression of clock genes in these cells, with significant intersubject variability of expression. In addition, our results reveal the existence of different chronotypes of clock gene expression patterns and suggest specific regulatory mechanisms in these human cells as compared to other peripheral tissues.
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Banco de datos:
MEDLINE
Asunto principal:
Relojes Biológicos
/
Leucocitos Mononucleares
/
Regulación de la Expresión Génica
/
Ritmo Circadiano
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Fr
Año:
2007
Tipo del documento:
Article