Primary antibiotic resistance in Helicobacter pylori strains isolated in northern and central Italy.
Aliment Pharmacol Ther
; 25(12): 1429-34, 2007 Jun 15.
Article
en En
| MEDLINE
| ID: mdl-17539982
ABSTRACT
BACKGROUND:
Helicobacter pylori resistance to antibiotics is increasing worldwide, and it reduces the efficacy of therapy.AIM:
To assess current primary antibiotic resistance in H. pylori strains isolated in Italy.METHODS:
Between June 2004 and June 2006, H. pylori strains were isolated consecutively in the two participating centres (Bologna, northern Italy; Rome, central Italy) from patients never previously treated for the infection. Isolated strains were tested for primary clarithromycin, metronidazole and levofloxacin resistance using as break point the minimal inhibitory concentration >/=1, >/=8 and >/=1 mg/L for the three antibiotics, respectively.RESULTS:
Overall, 255 H. pylori strains were evaluated. The resistance rate was 16.9% for clarithromycin, 29.4% for metronidazole and 19.1% for levofloxacin. Clarithromycin resistance was significantly higher in non-ulcer dyspepsia than in peptic ulcer patients (19.1% vs. 0%, P = 0.02), metronidazole resistance was higher in foreign than Italian patients (50% vs. 22.9%, P = 0.0004) and levofloxacin resistance was higher in old than younger patients (28.4% vs. 14.4%, P = 0.048). Levofloxacin resistance was also more frequent in those strains with either clarithromycin or metronidazole resistance.CONCLUSION:
A very high rate of primary resistance towards the tested antibiotics was detected in our study.
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Banco de datos:
MEDLINE
Asunto principal:
Resistencia a Medicamentos
/
Helicobacter pylori
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Infecciones por Helicobacter
/
Antibacterianos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Año:
2007
Tipo del documento:
Article