Effect of chronic stress and L-carnitine on rat stomach.
J Physiol Sci
; 57(3): 187-92, 2007 Jun.
Article
en En
| MEDLINE
| ID: mdl-17547782
ABSTRACT
BACKGROUND AND AIM:
L-Carnitine is an essential cofactor in the mitochondrial transfer of fatty acids, and it is also a scavenger of free radicals in mammalian tissues. The aim of the study was to determine the effect of L-carnitine on chronic restraint stress-induced gastric mucosal injury.METHODS:
Wistar rats were applied restraint stress (1 h/day) and L-carnitine (50 mg/kg) for 21 days. The lesion index, prostaglandin E(2) and mucus content, lipid peroxidation, superoxide dismutase, and catalase activity in gastric mucosa were evaluated.RESULTS:
Chronic restraint stress increased the lesion index, lipid peroxidation, and superoxide dismutase activity in gastric mucosa, and it decreased prostaglandin E(2) and mucus content. L-Carnitine treatment prevented the stress-induced increase in lesion index, lipid peroxidation and a stress-induced decline in prostaglandin E(2), and mucus content in gastric mucosa, but it increased catalase activity.CONCLUSIONS:
L-Carnitine prevents the occurrence of lesion by strengthening the gastric mucosal barrier and by reducing lipid peroxidation against the harmful effects of chronic restraint stress.
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Banco de datos:
MEDLINE
Asunto principal:
Estómago
/
Estrés Fisiológico
/
Carnitina
Límite:
Animals
Idioma:
En
Año:
2007
Tipo del documento:
Article