From bacterial genomes to novel antibacterial agents: discovery, characterization, and antibacterial activity of compounds that bind to HI0065 (YjeE) from Haemophilus influenzae.

Lerner, Claude G; Hajduk, Philip J; Wagner, Rolf; Wagenaar, Frank L; Woodall, Charlotte; Gu, Yu-Gui; Searle, Xenia B; Florjancic, Alan S; Zhang, Tianyuan; Clark, Richard F; Cooper, Curt S; Mack, Jamey C; Yu, Liping; Cai, Mengli; Betz, Steven F; Chovan, Linda E; McCall, J Owen; Black-Schaefer, Candace L; Kakavas, Stephan J; Schurdak, Mark E; Comess, Kenneth M; Walter, Karl A; Edalji, Rohinton; Dorwin, Sarah A; Smith, Richard A; Hebert, Eric J; Harlan, John E; Metzger, Randy E; Merta, Philip J; Baranowski, John L; Coen, Michael L; Thornewell, Susan J; Shivakumar, Annapur G; Saiki, Anne Y; Soni, Niru; Bui, Mai; Balli, Darlene J; Sanders, William J; Nilius, Angela M; Holzman, Thomas F; Fesik, Stephen W; Beutel, Bruce A

Lerner, Claude G; Hajduk, Philip J; Wagner, Rolf; Wagenaar, Frank L; Woodall, Charlotte; Gu, Yu-Gui; Searle, Xenia B; Florjancic, Alan S; Zhang, Tianyuan; Clark, Richard F; Cooper, Curt S; Mack, Jamey C; Yu, Liping; Cai, Mengli; Betz, Steven F; Chovan, Linda E; McCall, J Owen; Black-Schaefer, Candace L; Kakavas, Stephan J; Schurdak, Mark E; Comess, Kenneth M; Walter, Karl A; Edalji, Rohinton; Dorwin, Sarah A; Smith, Richard A; Hebert, Eric J; Harlan, John E; Metzger, Randy E; Merta, Philip J; Baranowski, John L; Coen, Michael L; Thornewell, Susan J; Shivakumar, Annapur G; Saiki, Anne Y; Soni, Niru; Bui, Mai; Balli, Darlene J; Sanders, William J; Nilius, Angela M; Holzman, Thomas F; Fesik, Stephen W; Beutel, Bruce A.

Afiliación

Lerner CG; Abbott Global Pharmaceutical Research and Development, Abbott Park, IL 60064-6098, USA.

Chem Biol Drug Des ; 69(6): 395-404, 2007 Jun.

Article en En | MEDLINE | ID: mdl-17581233

Asunto(s)

Adenosina Trifosfatasas/metabolismo; Antibacterianos/química; Proteínas Bacterianas/metabolismo; Química Farmacéutica/métodos; Haemophilus influenzae/metabolismo; Secuencia de Aminoácidos; Animales; Linfocitos B/metabolismo; Diseño de Fármacos; Genoma Bacteriano; Genómica; Espectroscopía de Resonancia Magnética; Espectrometría de Masas; Datos de Secuencia Molecular; Unión Proteica; Relación Estructura-Actividad

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Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Química Farmacéutica / Haemophilus influenzae / Adenosina Trifosfatasas / Antibacterianos Límite: Animals Idioma: En Año: 2007 Tipo del documento: Article

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