HLA-DRB1*1101 allele may be associated with bilateral Méniére's disease in southern European population.
Otol Neurotol
; 28(7): 891-5, 2007 Oct.
Article
en En
| MEDLINE
| ID: mdl-17592398
ABSTRACT
OBJECTIVE:
To analyze the associations of HLA-DRB1* and DQB1* Class II alleles in patients with bilateral Méniére's disease (MD). PATIENTS ANDMETHODS:
Eighty patients from two ethnically defined groups with definite bilateral MD, according to the diagnostic scale of the American Academy of Otolaryngology-Head and Neck Surgery, were compared with normal controls from the same origin in a prospective multicenter study. We performed an allele-specific amplification for HLA-DRB1* and DQB1* genes of the major histocompatibility complex.RESULTS:
The allele HLA-DRB1*1101 was associated with bilateral MD in the Mediterranean population (odds ratio, 3.65 [95% confidence intervals, 1.5-9.1], corrected p = 0.029); however, this allele was not associated in the group from Galicia (northwest of Spain). No differences were found in the distribution of alleles for the gene HLA-DQB1* between patients and controls.CONCLUSION:
The allele HLA-DRB1*1101 and the allelic group HLA-DRB1*11 may determine an increased susceptibility to develop bilateral MD in a southern European population.
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Banco de datos:
MEDLINE
Asunto principal:
Antígenos HLA-DR
/
Enfermedad de Meniere
Tipo de estudio:
Clinical_trials
/
Observational_studies
Límite:
Aged
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Female
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Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Año:
2007
Tipo del documento:
Article