Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
J Med Chem
; 50(19): 4699-709, 2007 Sep 20.
Article
en En
| MEDLINE
| ID: mdl-17705362
ABSTRACT
Structure-activity relationship studies centered around 3'-substituted (Z)-5-(2'-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glucocorticoid receptor modulators were identified with in vitro activity comparable to dexamethasone. In vivo evaluation of these compounds utilizing a 28 day mouse tumor xenograft model demonstrated efficacy equal to dexamethasone in the reduction of tumor volume.
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Banco de datos:
MEDLINE
Asunto principal:
Quinolinas
/
Benzopiranos
/
Receptores de Glucocorticoides
/
Mieloma Múltiple
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Año:
2007
Tipo del documento:
Article