Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients.
Schizophr Res
; 98(1-3): 105-10, 2008 Jan.
Article
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| MEDLINE
| ID: mdl-17961984
ABSTRACT
Genetic and molecular studies indicate that dysbindin-1 plays a role in the pathophysiology of schizophrenia. We examined dysbindin-1 mRNA in the hippocampal formation of patients with schizophrenia and found reduced expression in dentate granule and polymorph cells and in hippocampal field CA3, but not in CA1. Furthermore, there were positive correlations between dysbindin-1 mRNA and expression of synaptic markers known to be reduced in schizophrenia. Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Proteínas Portadoras
/
Hipocampo
Límite:
Humans
/
Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article