Developmental stability of taurine's activation on glycine receptors in cultured neurons of rat auditory cortex.
Neurosci Lett
; 430(1): 54-9, 2008 Jan 03.
Article
en En
| MEDLINE
| ID: mdl-17997039
ABSTRACT
Taurine is an endogenous amino acid that can activate glycine and/or gamma-aminobutyric acid type A (GABA(A)) receptors in the central nervous system. During natural development, taurine's receptor target undergoes a shift from glycine receptors to GABA(A) receptors in cortical neurons. Here, we demonstrate that taurine's receptor target in cortical neurons remains stable during in vitro development. With whole-cell patch-clamp recordings, we found that taurine always activated glycine receptors, rather than GABA(A) receptors, in neurons of rat auditory cortex cultured for 5-22 days. Our results suggest that the functional sensitivity of glycine and GABA(A) receptors to taurine is critically regulated by their developmental environments.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Corteza Auditiva
/
Taurina
/
Receptores de Glicina
/
Neuronas
Límite:
Animals
Idioma:
En
Año:
2008
Tipo del documento:
Article