Effect of hyperosmolality and cations on iodinated contrast medium-induced potassium release from human blood cells.
Radiat Med
; 25(9): 467-73, 2007 Nov.
Article
en En
| MEDLINE
| ID: mdl-18026905
ABSTRACT
PURPOSE:
Potassium release from blood cells is a contrast medium-induced phenomenon. The purposes of the study were to (1) assess the effect of hyperosmolality and of adding sodium ions and calcium ions to a solution on potassium release from human blood cells and (2) reevaluate the possibility of hemolysis as a cause of potassium elevation. MATERIALS ANDMETHODS:
Fresh human blood was mixed with a test solution to examine the temporal changes in the whole blood potassium levels and to calculate the potassium release rate. Test solutions included 5%, 20%, and 50% glucose; 0.9% and 10% NaCl; and 50% glucose mixed with various amounts of sodium and calcium ions. We also measured serum glutamine oxaloacetic acid transaminase (GOT) and serum lactate dehydrogenase (LDH) to evaluate the possibility of hemolysis.RESULTS:
Hyperosmolality using glucose solutions promoted higher potassium release. The average +/- SD potassium release rates were 7.3 +/- 2.4 micromol/min with 5% glucose, 13.5 +/- 2.3 micromol/min with 20% glucose, and 128.4 +/- 44.9 micromol/min with 50% glucose. The solutions including sodium ions showed lower release rates. The addition of sodium and calcium ions into 50% glucose significantly lowered the potassium release rates. No significant elevation of GOT or LDH was observed, and the possibility of hemolysis was eliminated.CONCLUSION:
Hyperosmolar glucose solution promoted potassium release, but the presence of sodium ions in the hypertonic solution inhibited it. In addition, there is no possibility of hemolysis as a cause of potassium release.
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Banco de datos:
MEDLINE
Asunto principal:
Potasio
/
Medios de Contraste
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2007
Tipo del documento:
Article