Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum.
Antimicrob Agents Chemother
; 52(2): 774-7, 2008 Feb.
Article
en En
| MEDLINE
| ID: mdl-18056275
ABSTRACT
Antibacterial agents are used in malaria therapy due to their effect on two prokaryote organelles, the mitochondrion and the apicoplast. We demonstrate here that the ribosome-blocking antibiotics telithromycin and quinupristin-dalfopristin, but not linezolid, inhibit the growth of Plasmodium falciparum. Both drugs induce delayed death in the parasite, suggesting that their effect involves the impairment of apicoplast translation processes.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
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Inhibidores de la Síntesis de la Proteína
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Virginiamicina
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Cetólidos
Límite:
Animals
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Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article