Acylguanidine inhibitors of beta-secretase: optimization of the pyrrole ring substituents extending into the S1' substrate binding pocket.

Jennings, Lee D; Cole, Derek C; Stock, Joseph R; Sukhdeo, Mohani N; Ellingboe, John W; Cowling, Rebecca; Jin, Guixian; Manas, Eric S; Fan, Kristi Y; Malamas, Michael S; Harrison, Boyd L; Jacobsen, Steve; Chopra, Rajiv; Lohse, Peter A; Moore, William J; O'Donnell, Mary-Margaret; Hu, Yun; Robichaud, Albert J; Turner, M James; Wagner, Erik; Bard, Jonathan

Jennings, Lee D; Cole, Derek C; Stock, Joseph R; Sukhdeo, Mohani N; Ellingboe, John W; Cowling, Rebecca; Jin, Guixian; Manas, Eric S; Fan, Kristi Y; Malamas, Michael S; Harrison, Boyd L; Jacobsen, Steve; Chopra, Rajiv; Lohse, Peter A; Moore, William J; O'Donnell, Mary-Margaret; Hu, Yun; Robichaud, Albert J; Turner, M James; Wagner, Erik; Bard, Jonathan.

Afiliación

Jennings LD; Chemical & Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. jenninl@wyeth.com

Bioorg Med Chem Lett ; 18(2): 767-71, 2008 Jan 15.

Article en En | MEDLINE | ID: mdl-18068983

Asunto(s)

Secretasas de la Proteína Precursora del Amiloide/antagonistas & inhibidores; Inhibidores Enzimáticos/farmacología; Guanidina/farmacología; Pirroles/química; Enfermedad de Alzheimer/enzimología; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Animales; Células CHO; Cricetinae; Cricetulus; Inhibidores Enzimáticos/química; Guanidina/química; Humanos

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Banco de datos: MEDLINE Asunto principal: Pirroles / Guanidina / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide Límite: Animals / Humans Idioma: En Año: 2008 Tipo del documento: Article

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