The effect of sports injury on insulin-like growth factor-I and type 3 procollagen: implications for detection of growth hormone abuse in athletes.
J Clin Endocrinol Metab
; 93(7): 2760-3, 2008 Jul.
Article
en En
| MEDLINE
| ID: mdl-18413420
ABSTRACT
CONTEXT A method to detect exogenously administered growth hormone (GH) based on the measurement of two GH-dependent markers, IGF-I and type 3 procollagen (P-III-P) has been proposed. Skeletal or soft tissue injury may alter these markers. Elevations in either of these proteins after injury might lead to a false accusation of doping with GH. OBJECTIVE:
The objective of the study was to assess the effect of musculoskeletal or soft tissue injury on IGF-I and P-III-P concentrations in amateur and elite athletes and assess the effect of injury on the proposed GH detection method.DESIGN:
This was a longitudinal observational study after sporting injury.SETTING:
The study was conducted at Southampton General Hospital and British Olympic Medical Centre.SUBJECTS:
Subjects included elite and amateur athletes after an injury. INTERVENTION Interventions included measurement of IGF-I and P-III-P and application of the GH-2000 discriminant function score up to 84 d after an injury as well as classification of injury by type and severity. OUTCOMEMEASURES:
IGF-I and P-III-P concentration and ability to detect GH abuse in athletes without the risk of false accusation because of an injury were measured.RESULTS:
There was no change in IGF-I concentration after an injury. By contrast, P-III-P concentrations rose by 41.1 +/- 16.6%, reaching a peak around 14 d after an injury. The rise in P-III-P varied according to injury type and severity. This rise had a trivial effect on the GH-2000 discriminant function score, and no subject reached the threshold needed for a doping offense.CONCLUSIONS:
Although there was a rise in P-III-P after injury, this was insufficient to invalidate the GH-2000 detection method based on IGF-I and P-III-P concentrations.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Traumatismos en Atletas
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Factor I del Crecimiento Similar a la Insulina
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Hormona de Crecimiento Humana
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Trastornos Relacionados con Sustancias
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Colágeno Tipo III
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Doping en los Deportes
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article