Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain.
J Clin Virol
; 42(4): 425-8, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18440271
ABSTRACT
BACKGROUND:
In spite of universal vaccination, several sporadic cases of mumps infection, which could produce outbreaks, are detected every year in different countries.OBJECTIVE:
Mumps virus strains causing two regional outbreaks in Asturias (Spain) were phylogenetically characterized. STUDYDESIGN:
Mumps virus strains, which were detected in samples from patients belonging to two regional outbreaks in Asturias, were characterized by sequencing of the SH gene and further alignment to homologous sequences of representative strains of the different mumps genotypes.RESULTS:
Two different strains (Ast/SP02 and Ast/SP07) were isolated. Sequence analysis revealed that while Ast/SP02 belonged to genotype H, Ast/SP07 was phylogenetically close to UK02-19, a reference strain for a new genotype. Both strains belonged to different genotypes from those used in the vaccination (Jeryl-Lynn strain is genotype A).CONCLUSION:
Mumps virus strains different from those used in vaccination program can cause mumps outbreaks even in vaccinated patients.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Brotes de Enfermedades
/
Paperas
/
Virus de la Parotiditis
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Humans
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Año:
2008
Tipo del documento:
Article