From ER to Eph receptors: new roles for VAP fragments.
Cell
; 133(6): 949-51, 2008 Jun 13.
Article
en En
| MEDLINE
| ID: mdl-18555770
ABSTRACT
Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Receptores de la Familia Eph
/
Proteínas de Transporte Vesicular
/
Esclerosis Amiotrófica Lateral
Límite:
Animals
/
Humans
Idioma:
En
Año:
2008
Tipo del documento:
Article