Five-year alterations in BMI are associated with clustering of changes in cardiovascular risk factors in a gender-dependant way: the Stanislas study.
Int J Obes (Lond)
; 32(8): 1279-88, 2008 Aug.
Article
en En
| MEDLINE
| ID: mdl-18607382
ABSTRACT
OBJECTIVE:
The purpose of the present longitudinal study was to describe the associations between the 5-year changes in body mass index (BMI) and alterations in the clusters of metabolic syndrome (MS)-related factors.METHODS:
The study population comprised 1099 middle-aged adults drawn from the Stanislas study. Individuals were stratified into four groups according to the 5-year changes in BMI (weight loss (<0 kg/m(2)), and weight gain (0-1, 1-2 and >2 kg/m(2))). Changes in various MS-related variables and clusters were compared between groups anthropometric indices, blood pressure, lipid and inflammatory markers, liver enzymes, uric acid and the five summary factors extracted by using factor analysis ('risk lipids', 'liver enzymes', 'inflammation', 'protective lipids' and 'blood pressure').RESULTS:
There was a strong linear trend between increasing BMI and worsening of risk lipids and blood pressure factors for both men and women (PCONCLUSION:
In our population, there was a strong linear trend between increasing BMI and worsening of various MS-related variables. More interestingly, the identification of five factors associated with BMI changes dependent to gender, support the hypothesis that weight gain, and probably obesity, trigger metabolic mechanisms that differ between men and women.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Índice de Masa Corporal
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Síndrome Metabólico
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article