A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
Nat Genet
; 40(10): 1204-10, 2008 Oct.
Article
en En
| MEDLINE
| ID: mdl-18758461
ABSTRACT
We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Haplotipos
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Leucemia Linfocítica Crónica de Células B
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Genoma Humano
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Mapeo Cromosómico
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Cromosomas Humanos
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Predisposición Genética a la Enfermedad
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Ligamiento Genético
Tipo de estudio:
Clinical_trials
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2008
Tipo del documento:
Article