[Presence of metallo beta-lactamases in imipenem-resistant Pseudomonas aeruginosa]. / Presencia de metalo-beta-lactamasas en Pseudomonas aeruginosa resistente a imipenem.
Rev Med Chil
; 136(4): 423-32, 2008 Apr.
Article
en Es
| MEDLINE
| ID: mdl-18769784
ABSTRACT
BACKGROUND:
Metallo-beta-lactamases (MBL) confer high resistance to carbapenems in Pseudomonas aeruginosa (Psae). They are encoded in mobile elements of different genes (VIM, IMP, SMP, GIM), along with other resistance genes.AIM:
To detect the presence of MBL in imipenem resistant Psae strains. MATERIAL ANDMETHODS:
Fifty-nine imipenem resistant Psae strains isolated from January 2004 to August 2005 in a University Clinical Hospital, were included. The presence of MBL was studied by Etest (phenotypic) and genotypic polymerase chain reaction (PCR) methods. To rule out a nosocomial outbreak, MBL positive strains were studied by pulse field gel electrophoresis.RESULTS:
The presence of MBL was detected in eleven strains. AH were type VIM and were not clonally related. There was no concordance between phenotypic and genotypic MBL detecting methods. All the strains were also multiresistant.CONCLUSIONS:
The presence of MBL was detected in 19% of imipenem resistant Psae strains.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Pseudomonas aeruginosa
/
Infecciones por Pseudomonas
/
Beta-Lactamasas
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Imipenem
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Antibacterianos
Límite:
Adolescent
/
Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
Es
Año:
2008
Tipo del documento:
Article