A free radical scavenger, edaravone, prevents ischemia-reperfusion injury in liver grafts from non-heart-beating donors.
Transplant Proc
; 40(7): 2171-4, 2008 Sep.
Article
en En
| MEDLINE
| ID: mdl-18790183
ABSTRACT
BACKGROUND:
Due to the increase in liver transplantation, the donor shortage has become a serious problem, requiring marginal, non-heart-beating donors (NHBDs). The aims of this study were to evaluate the cytoprotective effect of edaravone, a free radical scavenger, on warm ischemia-reperfusion (I/R) injury of liver grafts from NHBDs.METHODS:
Rat livers were harvested from heart-beating donors (HB group) or from NHBDs undergoing cardiac arrest for 30 minutes led by thoracotomy (NHB group), and reperfused for 60 minutes with Krebs-Henseleit bicarbonate buffer after cold preservation for 6 hours. In another group (ED group), warm ischemic livers from NHBDs were reperfused with buffer containing edaravone (1 mg/L) after cold preservation.RESULTS:
In the ED group, portal flow volume, bile production, and energy charge were significantly ameliorated. Lipid peroxidation, elevation of hepatic enzymes, and release of tumor necrosis factor-alpha and interleukin-1 beta were significantly alleviated, compared with the NHB group.CONCLUSIONS:
These results suggested that edaravone has suppressive effects on warm I/R injury in liver grafts from NHBDs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Antipirina
/
Depuradores de Radicales Libres
/
Trasplante de Hígado
Límite:
Animals
Idioma:
En
Año:
2008
Tipo del documento:
Article