[Prediction of glucose and insulin resistance disorders by using anthropometric parameters of central adiposity: PRED-IR study]. / Predicción de la glucemia basal alterada y resistencia a la insulina mediante el uso de medidas antropométricas de adiposidad central: estudio PRED-IR.

ABSTRACT

BACKGROUND AND OBJECTIVE: To assess the predictive value of some anthropometric parameters of central adiposity for the diagnosis of hyperglycemia and insulin resistance (IR) in the Spanish population. PATIENTS AND METHOD: Multicenter, cross-sectional study carried out in patients visited in primary care and in specialist clinics, of both sexes, between 18 and 79 years of age. IR was estimated in a subsample of patients by the Homeostasis Model Assessment (HOMA-IR). Patients with diagnosis of diabetes were excluded from the study. RESULTS: A total of 3,638 patients were evaluated, 690 out of these participated in the IR substudy. Waist circumference (WC) was the parameter with a better correlation with hyperglycemia and with IR (r = 0.29 and 0.38; p < 0.001). Each increase of 15 cm in the WC was associated with an increase of the risk hyperglycemia and IR (65% and 123%, respectively). The cut-off points that better discriminated men and women, with and without IR, were 105 and 91 cm, with a sensitivity of 62% (95% confidence interval [CI], 46-77%) and 71% (95% CI, 54-85%), and a specificity of 72% (95% CI, 66-78%) and 68 (95% CI, 63-73%), respectively. CONCLUSIONS: WC is a useful anthropometric measure for the detection of hyperglycemia and IR, and the optimal cut-off points for the Spanish population from which IR could be detected are 105 cm for men and 91 for women.