Prenatal exposure to lead, delta-aminolevulinic acid, and schizophrenia: further evidence.
Environ Health Perspect
; 116(11): 1586-90, 2008 Nov.
Article
en En
| MEDLINE
| ID: mdl-19057716
ABSTRACT
BACKGROUND:
A previously conducted study of prenatal lead exposure and schizophrenia using delta-aminolevulinic acid, a biologic marker of Pb exposure, in archived maternal serum samples collected from subjects enrolled in the Childhood Health and Development Study (1959-1966) based in Oakland, California, suggested a possible association between prenatal Pb exposure and the development of schizophrenia in later life.OBJECTIVES:
In the present study we extend these findings using samples collected from the New England cohort of the National Collaborative Perinatal Project (1959-1966). Using similar methods, in this study we found results that suggest a comparable association in this cohort.METHODS:
We pooled matched sets of cases and controls from both the California and New England sites using a multilevel random-intercept logistic regression model, accounting for matching and site structure as well as adjusting for maternal age at delivery and maternal education.RESULTS:
The estimated odds ratio for schizophrenia associated with exposure corresponding to 15 microg/dL of blood Pb was 1.92 (95% confidence interval, 1.05-3.87; p = 0.03).CONCLUSION:
Although several limitations constrain generalizability, these results are consistent with previous findings and provide further evidence for the role of early environmental exposures in the development of adult-onset psychiatric disorders.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Esquizofrenia
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Biomarcadores
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Ácido Aminolevulínico
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Plomo
Tipo de estudio:
Clinical_trials
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Prognostic_studies
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Año:
2008
Tipo del documento:
Article