[Probiotics and children: is an integration useful in allergic diseases?]. / Probiotici e bambini: è utile un'integrazione nei casi di allergia?
Pediatr Med Chir
; 30(4): 197-203, 2008.
Article
en It
| MEDLINE
| ID: mdl-19216203
ABSTRACT
Recent studies report that some probiotic strains are able to improve allergic diseases. For this reason, we would verify tolerability and efficacy of a industrial preparation of Lactobacillus paracasei (11,688; Proge Farm, Italy) and Lactobacillus salivarius (11,794; Proge Farm, Italy) and value their "in vitro" immunomodulatory effect. We know that, after birth, there's a persistence of Th2 immune response that predisposes to atopy, whereas commensal bacteria are able to induce a Th1 immune response that counter-balances the original response. The "in vivo" study was set up with the recruitment of 20 atopic pediatric patients treated 30 days with 2 doses of Fiorilac (Sharper, Italy), a preparation of the two strains in the proportion of 112. Only one patient referred significant improvements of atopic disease, 19 patients reported a good tolerability to the product and 3 patients had a regularization of intestinal function. Immunological tests showed an increase of Th1 immune response as in CD4+ lymphocytes percentage as of IL-12 and IL-10 cytokines production and a significant increase of natural killer (NK) activity, which predisposes to an active response to viral infections and neoplastic transformations.
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Banco de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
/
Dermatitis Perioral
/
Probióticos
/
Dermatitis Atópica
/
Lactobacillus
Tipo de estudio:
Observational_studies
Límite:
Child
/
Female
/
Humans
/
Male
Idioma:
It
Año:
2008
Tipo del documento:
Article