The role of predictive modelling in rationally re-engineering biological systems.
Nat Rev Microbiol
; 7(4): 297-305, 2009 04.
Article
en En
| MEDLINE
| ID: mdl-19252506
ABSTRACT
Technologies to synthesize and transplant a complete genome into a cell have opened limitless potential to redesign organisms for complex, specialized tasks. However, large-scale re-engineering of a biological circuit will require systems-level optimization that will come from a deep understanding of operational relationships among all the constituent parts of a cell. The integrated framework necessary for conducting such complex bioengineering requires the convergence of systems and synthetic biology. Here, we review the status of these rapidly developing interdisciplinary fields of biology and provide a perspective on plausible venues for their merger.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Biotecnología
/
Biología de Sistemas
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Modelos Biológicos
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Año:
2009
Tipo del documento:
Article