Progress and prospects: biological properties and technological advances of herpes simplex virus type 1-based amplicon vectors.
Gene Ther
; 16(6): 709-15, 2009 Jun.
Article
en En
| MEDLINE
| ID: mdl-19369969
ABSTRACT
The last two years have seen significant advances in our understanding of the cellular innate responses elicited or activated by the entry of amplicon particles, which may, in part, explain the transient nature of transgene expression often observed in cells infected with helper-free amplicon stocks. At the technological level, the most consistent progress has been in strategies to enhance the stability of transgene cassettes, either through integration into host chromosomes or through the conversion of the amplicon genome into a replication-competent extrachromosomal element.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Regulación Viral de la Expresión Génica
/
Herpesvirus Humano 1
/
Técnicas de Transferencia de Gen
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Silenciador del Gen
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Vectores Genéticos
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Inmunidad Innata
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2009
Tipo del documento:
Article