2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.
Bioorg Med Chem Lett
; 19(13): 3434-8, 2009 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-19473838
ABSTRACT
The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tiazoles
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Triazoles
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Telómero
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G-Cuádruplex
Idioma:
En
Año:
2009
Tipo del documento:
Article