Malaria antigen-mediated enhancement of interleukin-21 responses of peripheral blood mononuclear cells in African adults.
Exp Parasitol
; 122(1): 37-40, 2009 May.
Article
en En
| MEDLINE
| ID: mdl-19545527
ABSTRACT
We recently showed that IL-21 is associated with high level of anti-EBA-175 IgG1 and IgG3. Here we have investigated the ability of two malarial antigens, Glutamate-rich protein and merozoite surface protein 3 to induce IL-21 production from PBMCs from malaria-exposed and non-exposed donors. We found that malaria-exposed donors produced significantly more IL-21 compared to non-exposed donors. These data suggest that IL-21 could be involved in the acquisition of immunity to malaria.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plasmodium falciparum
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Leucocitos Mononucleares
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Proteínas Protozoarias
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Interleucinas
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Malaria Falciparum
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Antígenos de Protozoos
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2009
Tipo del documento:
Article