Endothelial cells promote the proliferation of lymphocytes partly through the Wnt pathway via LEF-1.
Biochem Biophys Res Commun
; 388(1): 67-72, 2009 Oct 09.
Article
en En
| MEDLINE
| ID: mdl-19643084
ABSTRACT
The function of T cells and B cells is to recognize specific "non-self" antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally eliminate specific pathogens or pathogen-infected cells. Endothelial cells (ECs) can trigger the activation of T cells through their class I and class II MHC molecules. In this study, we examined the effect of ECs on the proliferation of lymphocytes. We report that the proliferation of T and B cells can be improved by interaction with ECs. LEF-1 is one of the main molecular mediators in this process, and the inhibition of LEF-1 induces apoptosis. These results suggest that LEF-1 modulates positively the proliferation of lymphocytes induced by their interaction with ECs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Endotelio Vascular
/
Activación de Linfocitos
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Linfocitos
/
Proteínas Wnt
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Factor de Unión 1 al Potenciador Linfoide
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2009
Tipo del documento:
Article