Capecitabine in combination with oxaliplatin or irinotecan in elderly patients with advanced colorectal cancer: results of a randomized phase II study.
Ann Oncol
; 21(4): 781-786, 2010 Apr.
Article
en En
| MEDLINE
| ID: mdl-19713248
ABSTRACT
BACKGROUND:
To determine the efficacy and tolerability of capecitabine combined with oxaliplatin (CAPOX) or irinotecan (CAPIRI) as first-line treatment in patients with advanced/metastatic colorectal cancer aged > or =70 years. PATIENTS ANDMETHODS:
Patients aged > or =70 years were randomly assigned to receive CAPOX [oxaliplatin 65 mg/m(2) intravenously (i.v.) days 1 and 8 and capecitabine 1000 mg/m(2) orally b.i.d. days 1-14; q21d] or CAPIRI (irinotecan 80 mg/m(2) i.v. days 1 and 8 and capecitabine 1000 mg/m(2) orally b.i.d. days 1-14; q21d). The primary study end point was overall response rate (ORR).RESULTS:
Ninety-four patients were enrolled. In an intent-to-treat analysis, 2 complete responses (CRs) and 16 partial responses (PRs) were reported with CAPOX (ORR 38%), and 2 CRs and 15 PRs with CAPIRI (ORR 36%; P = 0.831). Median time to progression was 8 months for CAPOX and 7 months for CAPIRI (P = 0.195), with median survival times of 19.3 months and 14.0 months (P = 0.165), respectively. Global health status was improved in 45% and in 21% of patients in the CAPOX and CAPIRI arms, respectively. The most common treatment-related grade 3-4 adverse events in CAPIRI versus CAPOX patients were diarrhea (32% versus 15%; P = 0.052) and neutropenia (23% versus 6%; P = 0.021).CONCLUSION:
CAPOX and CAPIRI had similar efficacy in elderly patients, although CAPOX seemed to be better tolerated.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Organoplatinos
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Anciano
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Camptotecina
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Carcinoma
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Neoplasias Colorrectales
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Protocolos de Quimioterapia Combinada Antineoplásica
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Desoxicitidina
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Fluorouracilo
Tipo de estudio:
Clinical_trials
Límite:
Aged80
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Female
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Humans
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Male
Idioma:
En
Año:
2010
Tipo del documento:
Article