[Usefulness and cogency of gene probes in paternity questions (Personal experiences: 1989/90]. / Brauchbarkeit und Beweisert von Gen-Sonden in Abstammungsfragen (Eigene Erfahrungen: 1989/90).
Wien Klin Wochenschr
; 102(22): 673-6, 1990 Nov 23.
Article
en De
| MEDLINE
| ID: mdl-1980178
ABSTRACT
In cases of disputed parentage usually more than 20 polymorphic systems (red and white cell antigens, serum markers and enzyme markers) have to be analyzed using a battery of different techniques. A more recent method involving analysis of restriction fragment length polymorphism in highly polymorphic genes allows assignment of offspring to their parents. To test the latter method, 28 paternity cases were studied in parallel using conventional systems and detection of RFLPs of probes MS 1, MS 31, MS 43, and g 3, developed by Jeffreys et al. Furthermore, the cogency of exclusion of parentage, the average power of exclusion and the probability of parentage is calculated using published mutation rates and gene frequencies of the four probes. In conclusion, use of the four gene probes has both theoretically and practically turned out to be a powerful method for parentage testing.
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Banco de datos:
MEDLINE
Asunto principal:
Paternidad
/
Antígenos de Grupos Sanguíneos
/
Marcadores Genéticos
Límite:
Humans
Idioma:
De
Año:
1990
Tipo del documento:
Article