Docosahexaenoic acid downregulates interferon gamma-induced expression of CXCL16 in human aortic smooth muscle cells.
Biochem Biophys Res Commun
; 391(1): 609-14, 2010 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-19932682
ABSTRACT
CXCL16 is a chemokine that is expressed in both transmembrane and secreted isoforms. Both variants have been implicated in atherosclerosis. Increased CXCL16 expression on the surface of human aortic smooth muscle cells induced by interferon gamma (IFNgamma) signaling results in enhanced oxidized low density lipoprotein uptake and enhanced recruitment of pro-inflammatory cells. Docosahexaenoic acid (DHA), an omega-3 fatty acid, is known to inhibit IFNgamma signaling in inflammatory cells. Therefore, we have investigated the effects of DHA treatment on the ability of IFNgamma to induce CXCL16 expression in human aortic smooth muscle cells. We observed that DHA treatment significantly reduced IFNgamma-induced CXCL16 expression. As a result, the pro-atherosclerotic functions of CXCL16 were also inhibited. Furthermore, IFNgamma-induced STAT1 phosphorylation was inhibited by DHA, suggesting a potential mechanism. In conclusion, our data suggest inhibition of IFNgamma signaling as one of the mechanisms behind the beneficial effects of DHA during atherosclerosis. These findings may prove to be important in other disease fields that identify IFNgamma as a regulator.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aorta
/
Ácidos Docosahexaenoicos
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Interferón gamma
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Quimiocinas CXC
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Miocitos del Músculo Liso
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Receptores Depuradores
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article