Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.
Viral Immunol
; 22(6): 457-62, 2009 Dec.
Article
en En
| MEDLINE
| ID: mdl-19951183
ABSTRACT
Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-kappaB (NF-kappaB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-kappaB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Monocitos
/
FN-kappa B
/
Virus Pichinde
/
Infecciones por Arenaviridae
/
Virus Defectuosos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
2009
Tipo del documento:
Article