Hippocampus and olfactory discrimination learning: effects of entorhinal cortex lesions on olfactory learning and memory in a successive-cue, go-no-go task.
Behav Neurosci
; 105(1): 111-9, 1991 Feb.
Article
en En
| MEDLINE
| ID: mdl-2025384
ABSTRACT
Three experiments assessed the effect of entorhinal cortex lesions on olfactory learning and memory using a successive-cue olfactory discrimination paradigm. In contrast to the results of other studies that used a simultaneous-cue paradigm, lesions of the entorhinal cortex facilitated rats' acquisition of individual odor discrimination problems, with no impairment in memory for the individual odors across both short (24-hr) and long (65-day) retention intervals and despite limited training. When considered together with previous observations of facilitation or impairment in learning after damage to the hippocampal system, the present data suggest that the hippocampus is preferentially involved in encoding relations among multiple stimuli. By this account, facilitation of performance is due to an interaction between hippocampal system dysfunction and task conditions that hinder direct comparisons among cues.
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Banco de datos:
MEDLINE
Asunto principal:
Nivel de Alerta
/
Recuerdo Mental
/
Olfato
/
Aprendizaje Discriminativo
/
Hipocampo
/
Sistema Límbico
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Año:
1991
Tipo del documento:
Article