Kinetics and mechanism of oxidation of promazine and promethazine by ferric perchlorate.
J Pharm Sci
; 67(2): 168-71, 1978 Feb.
Article
en En
| MEDLINE
| ID: mdl-202690
ABSTRACT
The equilibrium constants, kinetics, and mechanism of promazine and promethazine oxidation by ferric perchlorate were investigated at different temperatures and acidities using a stopped-flow spectrophotometric technique. The overall reaction can be represented as follows (formula see text) where P+ represents the radical cation corresponding to the phenothiazine derivative. The equilibrium quotients were evaluated at 1.00 M HClO4, 25.0 degrees, and ionic strength 1.0 M. The kinetics of reaction follow the equation -d[P] divided by dt = k1[Fe3+][P]-k-1[Fe2+][P+] The rate constants k1 and k-1 are independent of acidity and are related to the corresponding equilibrium quotients.
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Banco de datos:
MEDLINE
Asunto principal:
Promazina
/
Prometazina
/
Percloratos
Idioma:
En
Año:
1978
Tipo del documento:
Article