Cystatin C and risk of vascular and nonvascular mortality: a prospective cohort study of older men.
J Intern Med
; 268(2): 145-54, 2010 Aug.
Article
en En
| MEDLINE
| ID: mdl-20337853
ABSTRACT
OBJECTIVE:
To assess the relevance of cystatin C, as a marker of mild-to-moderate renal impairment, for vascular and nonvascular mortality in older people.DESIGN:
Prospective cohort study.SETTING:
Re-survey in 1997 to 1998 of survivors in the 1970 Whitehall study of London civil servants.SUBJECTS:
Five thousand three hundred and seventy-one men (mean age at resurvey 77 years) who took part in the resurvey and had plasma cystatin C concentration measured. MAIN OUTCOMEMEASURES:
Cause-specific mortality over subsequent 11 years (1997 to 2008).METHODS:
Cox regression was used to estimate the associations of cystatin C with vascular and nonvascular mortality, before and after adjustment for prior disease and other risk factors (including lifetime blood pressure).RESULTS:
During an 11.0-year follow-up period, there were 1171 deaths from vascular causes [26 per 1000 per year (py)] and 1615 deaths from nonvascular causes (36 per 1000 py). Compared with men with cystatin C in the bottom fifth of the distribution, men in the top 10th had about two-fold higher mortality rates from vascular and nonvascular mortality (fully adjusted P both <0.001) even after adjustment for prior disease and all measured confounders, including lifetime blood pressure. The fully adjusted relative risks per 50% higher cystatin C concentrations were 1.66 [95% CI 1.48 to 1.85] for vascular mortality, 1.92 [95% CI 1.66 to 2.22] for ischaemic heart disease mortality and 1.46 [95% CI 1.31 to 1.61] for nonvascular mortality.CONCLUSIONS:
In older men, plasma concentration of cystatin C, probably as a marker of mild renal disease, is a strong independent predictor of both vascular and nonvascular mortality.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Mortalidad
/
Cistatina C
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Año:
2010
Tipo del documento:
Article