Relationship between DNA repair and formation of sister chromatid exchanges and chromatid aberrations under the influence of poly(ADP-ribose) polymerase inhibition by 3-aminobenzamide.
Cytogenet Genome Res
; 128(1-3): 118-23, 2010.
Article
en En
| MEDLINE
| ID: mdl-20389038
ABSTRACT
The mechanisms of formation of sister chromatid exchanges (SCEs) and chromosome aberrations following inhibition of poly(ADP-ribose) polymerase by 3-aminobenzamide were studied in Chinese hamster ovary cell lines deficient in different repair pathways. The results confirm earlier findings that (a) the 'spontaneous' SCEs are formed due to the incorporated BrdU in the DNA, (b) 'spontaneous' and induced SCEs originate from different mechanisms, and (c) SCEs and chromatid exchanges are formed by different pathways.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Intercambio de Cromátides Hermanas
/
Benzamidas
/
Reparación del ADN
/
Inhibidores de Poli(ADP-Ribosa) Polimerasas
Límite:
Animals
/
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article