2-Substituted N-aryl piperazines as novel triple reuptake inhibitors for the treatment of depression.
Bioorg Med Chem Lett
; 20(13): 3941-5, 2010 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-20570146
ABSTRACT
Recently a class of compounds known as triple reuptake inhibitors has emerged as a new strategy for the treatment of depression. These compounds work by simultaneously inhibiting the synaptic reuptake of serotonin, norepinephrine and dopamine. In this Letter we describe the optimization of a novel series of 2-substituted N-aryl piperazine based triple reuptake inhibitors.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Inhibidores de la Captación de Neurotransmisores
/
Depresión
/
Antidepresivos
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article