Identification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution.
Bioorg Med Chem Lett
; 20(15): 4631-4, 2010 Aug 01.
Article
en En
| MEDLINE
| ID: mdl-20576431
ABSTRACT
Exendin-4, a glucagon-like peptide 1 receptor agonist, is a potent therapeutic xenopeptide hormone for the treatment of type 2 diabetes. In order to further improve in vivo activity, we examined the introduction of sialyl N-acetyllactosamine (sialyl LacNAc) to exendin-4. The glycosylated analogue having sialyl LacNAc at position 28 was found to have improved in vivo activity with prolonged glucose-lowering activity.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Ponzoñas
/
Glucemia
/
Hipoglucemiantes
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Año:
2010
Tipo del documento:
Article