Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.

Hong, Qingmei; Bakshi, Raman K; Dellureficio, James; He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H; Sebhat, Iyassu K; Guo, Liangqin; Liu, Jian; Jian, Tianying; Tang, Rui; Kalyani, Rubana N; Macneil, Tanya; Vongs, Aurawan; Rosenblum, Charles I; Weinberg, David H; Peng, Qingping; Tamvakopoulos, Constantin; Miller, Randy R; Stearns, Ralph A; Cashen, Doreen; Martin, Willian J; Chen, Airu S; Metzger, Joseph M; Chen, Howard Y; Strack, Allison M; Fong, Tung M; Maclntyre, Euan; Van der Ploeg, Lex H T; Wyvratt, Matthew J; Nargund, Ravi P

Hong, Qingmei; Bakshi, Raman K; Dellureficio, James; He, Shuwen; Ye, Zhixiong; Dobbelaar, Peter H; Sebhat, Iyassu K; Guo, Liangqin; Liu, Jian; Jian, Tianying; Tang, Rui; Kalyani, Rubana N; Macneil, Tanya; Vongs, Aurawan; Rosenblum, Charles I; Weinberg, David H; Peng, Qingping; Tamvakopoulos, Constantin; Miller, Randy R; Stearns, Ralph A; Cashen, Doreen; Martin, Willian J; Chen, Airu S; Metzger, Joseph M; Chen, Howard Y; Strack, Allison M; Fong, Tung M; Maclntyre, Euan; Van der Ploeg, Lex H T; Wyvratt, Matthew J; Nargund, Ravi P.

Afiliación

Hong Q; Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. qingmei_hong@merck.com

Bioorg Med Chem Lett ; 20(15): 4483-6, 2010 Aug 01.

Article en En | MEDLINE | ID: mdl-20598533

Asunto(s)

Ligandos; Receptor de Melanocortina Tipo 4/agonistas; Animales; Humanos; Piperazina; Piperazinas/síntesis química; Piperazinas/química; Piperazinas/farmacocinética; Ratas; Ratas Sprague-Dawley; Receptor de Melanocortina Tipo 4/metabolismo; Relación Estructura-Actividad

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor de Melanocortina Tipo 4 / Ligandos Límite: Animals / Humans Idioma: En Año: 2010 Tipo del documento: Article

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