Nitric oxide modulates the expression of endothelial cell adhesion molecules involved in angiogenesis and leukocyte recruitment.
Exp Cell Res
; 317(1): 29-41, 2011 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-20813110
ABSTRACT
Tumor angiogenesis and immune response have in common to be cell recognition mechanisms, which are based on specific adhesion molecules and dependent on nitric oxide (NO(â¢)). The aim of the present study is to deepen the mechanisms of angiogenesis and inflammation regulation by NO(â¢) to find out the molecular regulation processes that govern endothelial cell permeability and leukocyte transmigration. Effects of NO(â¢), either exogenous or produced in hypoxic conditions, were studied on microvascular endothelial cells from skin and lymph node because of their strong involvement in melanoma progression. We found that NO(â¢) down-regulation of pseudo-vessel formation was linked to a decrease in endothelial cell ability to adhere to each other which can be explain, in part, by the inhibition of PECAM-1/CD31 expression. On the other hand, NO(â¢) was shown to be able to decrease leukocyte adhesion on an endothelial monolayer, performed either in static or in rolling conditions, and to modulate differentially CD34, ICAM-1/CD54, ICAM-2/CD102 and VCAM-1/CD106 expression. In conclusion, during angiogenesis and leukocyte recruitment, NO(â¢) regulates cell interactions by controlling adhesion molecule expression and subsequently cell adhesion. Moreover, each endothelial cell type presents its own organospecific response to NO(â¢), reflecting the functions of the tissue they originate from.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Moléculas de Adhesión Celular
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Quimiotaxis de Leucocito
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Neovascularización Fisiológica
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Células Endoteliales
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Óxido Nítrico
Límite:
Humans
Idioma:
En
Año:
2011
Tipo del documento:
Article