Increased level of hepatocyte growth factor in children with dengue virus infection.
Ann Trop Paediatr
; 30(3): 213-8, 2010.
Article
en En
| MEDLINE
| ID: mdl-20828454
ABSTRACT
BACKGROUND:
Evidence of hepatocellular damage is common in dengue-infected individuals. Hepatocyte growth factor (HGF), a key cytokine responsible for liver regeneration, may play a prognostic role in dengue virus infection.AIM:
To determine the relationship between serum HGF level and disease severity in patients with dengue virus infection.METHODS:
Serum samples from 27 children [17 dengue fever (DF), ten dengue haemorrhagic fever (DHF)] with serologically confirmed dengue virus infection during the febrile, toxic stages and at follow-up were analysed for HGF. Serum samples obtained from nine healthy children served as the control group.RESULTS:
In dengue-infected patients, serum HGF was significantly higher at the febrile and toxic stages than at follow-up (p<0.05). In comparison with DF, patients with DHF had a greater level of HGF at the febrile stage (p<0.05). A cut-off HGF level of 1220 pg/mL obtained during the febrile stage showed a sensitivity of 90% and a specificity of 53% for predicting clinical progression to DHF (area under the ROC curve 0.75).CONCLUSION:
Serum HGF level at the early stage of dengue virus infection is elevated and may be a useful predictor for clinical progression to DHF.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Factor de Crecimiento de Hepatocito
/
Dengue
/
Virus del Dengue
Tipo de estudio:
Prognostic_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2010
Tipo del documento:
Article