Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor.
Trends Endocrinol Metab
; 21(11): 691-8, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-20846877
ABSTRACT
Breast and prostate cancers are hormone-sensitive malignancies that afflict millions of women and men. Although prolactin (PRL) is known as a survival factor that supports tumor growth and confers chemoresistance in both cancers, its precise role in these tumors has not been studied extensively. Growth hormone and placental lactogen also bind PRL receptor (PRLR) and mimic some of the actions of PRL. Blockade of the PRLR represents a novel treatment for patients with advanced breast or prostate cancer with limited therapeutic options. This review discusses different approaches for generating PRLR antagonists. Emphasis is placed on technological advances which enable high-throughput screening for small molecule inhibitors of PRLR signaling that could serve as oral medications.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
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Receptores de Prolactina
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Neoplasias de la Mama
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Carcinoma
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Terapia Molecular Dirigida
Tipo de estudio:
Evaluation_studies
/
Prognostic_studies
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Año:
2010
Tipo del documento:
Article