Naphthylchalcones induce apoptosis and caspase activation in a leukemia cell line: The relationship between mitochondrial damage, oxidative stress, and cell death.
Bioorg Med Chem
; 18(22): 8026-34, 2010 Nov 15.
Article
en En
| MEDLINE
| ID: mdl-20952199
ABSTRACT
In this study, we investigated the effects of 24 chalcone derivatives from 2-naphthylacetophenone toward a lymphoblastic leukemia cell line (L1210). Three compounds, called R7, R13, and R15, presented concentration- and time-dependent cytotoxicity and induced cellular death by apoptosis via mitochondrial injury and oxidative stress. The effects of these compounds appear to occur through different mechanisms because R13 and R7 induced a greater disturbance of mitochondrial potential, and all compounds induced disturbances of cellular ATP content and increased caspase-3 activity before cellular death. These compounds also interfered with antioxidant enzymes activities and GSH content through different mechanisms.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Leucemia
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Chalcona
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Apoptosis
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Estrés Oxidativo
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Chalconas
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Caspasa 3
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Mitocondrias
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Antineoplásicos
Límite:
Humans
Idioma:
En
Año:
2010
Tipo del documento:
Article